Epistemology- How do we know what we think we know?

Epistemology is another core concept of philosophy which seeks to explain the authorities in which we place our trust while seeking truth. There are many different ways to validate knowledge—God, science, God as science, experience, sensory perceptions, feeling, the self, etc.
For example, in which authorities are Joel and Clementine trusting when they decide to fall in love all over again at the end of the film despite having been (re)exposed to the darker side of their past relationship? Does the nature of our knowing solely equate to the work of neurons rewiring our brains according to our experiences, the hormones released when we feel pleasure vs. pain, or can we "know" something in a spiritual sense too? Joel and Clementine’s experience (as well as Mary and Howard’s) flirts with themes of fate and at the very least gives rise to taking a second glance at the meaning of the phrase “meant to be together.”